Alterations in synaptic function and plasticity in Huntington disease
نویسندگان
چکیده
منابع مشابه
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متن کاملStriatal Synaptic Dysfunction and Hippocampal Plasticity Deficits in the Hu97/18 Mouse Model of Huntington Disease
Huntington disease (HD) is a fatal neurodegenerative disorder caused by a CAG repeat expansion in the gene (HTT) encoding the huntingtin protein (HTT). This mutation leads to multiple cellular and synaptic alterations that are mimicked in many current HD animal models. However, the most commonly used, well-characterized HD models do not accurately reproduce the genetics of human disease. Recent...
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15 صفحه اولAlterations in brain connectivity due to plasticity and synaptic delay
Brain plasticity refers to brain's ability to change neuronal connections, as a result of environmental stimuli, new experiences, or damage. In this work, we study the effects of the synaptic delay on both the coupling strengths and synchronisation in a neuronal network with synaptic plasticity. We build a network of Hodgkin-Huxley neurons, where the plasticity is given by the Hebbian rules. We...
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ژورنال
عنوان ژورنال: Journal of Neurochemistry
سال: 2019
ISSN: 0022-3042,1471-4159
DOI: 10.1111/jnc.14723